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Drug Abuse in Adolescence - Denise De Micheli

Year 2016


Part I Adolescence: Psychobiological TransformationsChapter 1 The Neurohormonal System in AdolescenceThe Neurohumoral System in AdolescenceMajor Pubertal Changes Due to Hormone SecretionThe Hypothalamic-Pituitary-Gonadal SystemThe Hypothalamic-Pituitary-Adrenal SystemReferencesChapter 2 Cognitive Development, Learning and Drug UseUse of Cannabis in Adolescence—Epidemiology and Risk FactorsConclusionReferencesChapter 3 Neural Development in AdolescenceIntroductionDopamineNorepinephrineSerotoninGlutamateReferencesPart II Adolescence, Drugs, and the Central Nervous SystemChapter 4 Neural Basis of Drug AddictionThe Reward SystemReceptorsNeurotransmittersThe Mesocorticolimbic Reward CircuitAnimal Models of Drug AddictionThe Role of Learning and Memory Processes in AddictionThe Neural Stages of AddictionThe Reward System in the Adolescent BrainSummaryReferencesChapter 5 Neurobiology of the Action of Drugs of AbuseReferencesChapter 6 Neuroimaging of the Human Brain in Adolescent Substance UsersIntroductionThe Adolescent PeriodAdolescent Brain Development, Cognition and Substance UseKey Brain Systems Relevant to Adolescent Substance MisuseMethodSearch MethodResultsSummary of sMRI FindingsSummary of DTI FindingsResponse to Drug-Related CuesWorking MemoryVerbal LearningInhibitory ControlSummary of fMRI ResultsSummary of Findings Across ModalitiesCannabisAlcoholInhalantsClinical Applications for Neuroimaging in Adolescent Substance MisuseConclusionsReferencesChapter 7 Alcohol Abuse in Adolescents: Relevance of Animal Models and Experimental Results in Adolescent AnimalsIntroductionUse of Animal Models to Analyze Drug Use and Risk Factors Associated with Drugs in the Course of Development and Their Effects Along LifeDifferences in the Sedative Effects and Locomotor Deficit Induced by Alcohol and in the Ability to Metabolize itDifferences in the Perception of the Reinforcing Effects of AlcoholMain Neurochemical Findings in Adolescent and Adult Animals in Response to Drugs of AbuseReferencesChapter 8 FMRI Studies of the Adolescent Reward System: The Triadic Model PerspectiveAdolescence, Motivated Behavior, and the Triadic ModelAdolescent BehaviorBrain DevelopmentThe Triadic Neural Systems ModelfMRI Task Paradigms to Assess Decision Making and MotivationBasic Principles Underlying Reward-Related ParadigmsFindings of Reward-Related fMRI StudiesConclusionReferencesChapter 9 Sleep and Drug Abuse during AdolescenceIntroductionSleep Patterns During AdolescenceSleep Architecture and Total Sleep TimeChronotypesSleep DisordersEpidemiology of Drug Abuse and Sleep Complaints Among AdolescentsEffects of Drug Abuse on SleepAlcoholTobaccoOpioidsCocaineCannabisEcstasySleep During Adolescence as a Predisposing Factor to Drug AbuseChronotype and Drug AbuseEveningness and Sleep DeprivationBehavior as a Mediator Between Sleep and Drug AbuseSelf-MedicationSleep HygieneConclusionsReferencesChapter 10 Neurological and Cognitive Changes Resulting from Chronic Drug UseIntroductionCognitive Aspects During Adolescence and Neural Mechanisms of Decision-MakingCognitive Changes in Adolescents and Adults Suffering from Substance DependenceEvidence for Cognitive Changes Among Chronic Users of Alcohol and Other DrugsAlcoholTobaccoIllicit Psychoactive SubstancesMarijuanaCocaineAmphetaminesEcstasyHallucinogensRehabilitation of Preserved Brain FunctionsReferencesChapter 11 Relationships Between Mood Disorders and Substance Abuse During AdolescenceIntroductionMood Disorders During AdolescenceDiagnosisPrevalenceComorbiditiesImpactTreatmentRelationships Between Mood Disorders and Substance Abuse in AdolescentsPrevalence of ComorbidityImpact of ComorbidityTreatment of Comorbidity Between Mood Disorders and Substance Abuse or DependenceConclusionReferencesChapter 12 Patterns of Drug Use in Carriers of Attention Deficit and Hyperactivity Disorder (ADHD)BackgroundADHD and Drug AbuseADHD and Nicotine UseADHD and Alcohol AbuseADHD and Marijuana UseADHD and Cocaine UseADHD, Conduct Disorder, and Drug UseTherapeutic ApproachReferences
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