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Oxygen Transport to Tissue XXXVI - Harold M. Swartz

Year 2014


Chapter 1 Mitochondrial Genetic Abnormalities After Radiation Exposure1 Introduction2 Methods3 Results4 Discussion5 ConclusionChapter 2 Crediting Six Discoverers of OxygenChapter 3 Hypoxia in Tumors: Pathogenesis-Related Classification, Characterization of Hypoxia Subtypes, and Associated Biological and Clinical Implications1 Introduction2 Chronic Hypoxia3 Acute Hypoxia4 Hypoxia-Associated Biological and Clinical Implications5 ConclusionsChapter 4 Heterogeneity in Tissue Oxygenation: From Physiological Variability in Normal Tissues to Pathophysiological Chaos in Malignant Tumours1 Heterogeneity of Blood Flow2 Heterogeneity of Oxygen Supply: The Tissue pO2 Histogram3 Physiological Response of Tissue O2 Supply4 Pathological Responses of Tissue O2 Supply in Normal Microvasculature and in Malignant Tumours5 ConclusionsChapter 5 Oxygen Diffusion: An Enzyme-Controlled Variable Parameter1 Introduction2 Methods3 Results4 Discussion5 ConclusionChapter 6 Role of Microvascular Shunts in the Loss of Cerebral Blood Flow Autoregulation1 Introduction2 Methods2.1 Two Photon Laser Scanning Microscopy Studies2.1.1 Microvascular Shunting by Increasing Intracranial Pressure2.1.2 Increasing CPP Attenuates the Transition from Capillary Flow to Microvascular Shunts with Increasing ICP2.2 Multimodal Monitoring System in Patients3 Results4 Discussion5 ConclusionsChapter 7 Impact of Hypoxia-Related Tumor Acidosis on Cytotoxicity of Different Chemotherapeutic Drugs In Vitro and In Vivo1 Introduction2 Material and Methods2.1 Cell Lines2.2 Chemotherapy2.3 Forcing Glycolytic Metabolism2.4 Measurement of Apoptosis Induction and Cell Survival3 Results4 DiscussionChapter 8 The Founding of ISOTT: The Shamattawa of Engineering Science and Medical Science1 The Merging of Engineering and Medical SciencesChapter 9 A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism1 Introduction2 Fiber Optics and MRI, the Issues and Solutions to Multimodality Imaging3 Advantages of Combining NIRS and MRI4 Studying Cellular Redox Potential5 Measuring Brain Oxidative State in Hypoxia6 Measuring Cerebral Metabolic Rate for Oxygen (CMRO2) in Hypoxia-Ischemia7 ConclusionChapter 10 Advances in Probes and Methods for Clinical EPR Oximetry1 Introduction2 Probes for Clinical EPR Oximetry2.1 India Ink2.2 High-Sensitive Crystalline Probes2.3 Polymer-Encapsulated High-Sensitive Crystalline Probes for Safe Use in Humans2.4 Implantable Oxygen Sensors (ImOS) for Deep-Tissue Oximetry2.5 Multisite Oximetry3 First Clinical Oximetry Data4 ConclusionChapter 11 Real-Time, In Vivo Determination of Dynamic Changes in Lung and Heart Tissue Oxygenation Using EPR Oximetry1 Introduction2 Methods2.1 Fabrication of Implantable Resonators2.2 Implantation of Resonators for Heart and Lung Oximetry2.3 EPR Oximetry Measurements3 Results and Discussion4 ConclusionChapter 12 Modulation of Hypoxia by Magnetic Nanoparticle Hyperthermia to Augment Therapeutic Index1 Introduction2 Methods2.1 Cell Lines and Culture2.2 Murine Model of Breast Cancer2.3 Magnetic NPH and Temperature Measurements2.4 EPR Oximetry2.5 Inductively Coupled Plasma Mass Spectrometry (ICP-MS)2.6 Transmission Electron Microscopy (TEM)2.7 Statistical Analysis3 Results4 ConclusionsChapter 13 Skeletal Muscle and Glioma Oxygenation by Carbogen Inhalation in Rats:1 Introduction2 Methods2.1 Single-Probe Implantable Oxygen Sensors2.2 Animal Preparation2.2.1 Tumor Model and Implantation of ImOS into the Skeletal Muscle and 9L Tumors2.2.2 Hyperoxia Challenge2.3 EPR Oximetry2.4 Histological Analysis2.5 Statistical Analysis3 Results4 DiscussionChapter 14 Recurrent Low-Dose Chemotherapy to Inhibit and Oxygenate Head and Neck Tumors1 Introduction2 Methods2.1 Head and Neck Tumor Xenografts and Experimental Groups2.2 In Vivo EPR Oximetry2.3 Immunohistochemistry Analysis of the Tumors2.4 Statistical Analysis3 Results4 ConclusionsChapter 15 How In Vivo EPR Measures and Images Oxygen1 Spin Probe2 Imaging Methods2.1 Projection-Based Reconstruction2.2 Single Point Imaging2.3 Pulse Sequences and 4D Images3 Importance of Spin-Lattice Relaxation Imaging4 ConclusionsChapter 16 What We Learn from In Vivo EPR Oxygen Images2 Methods3 Results4 Discussion and ConclusionsChapter 17 EPR Image Based Oxygen Movies for Transient Hypoxia1 Introduction2 Methods2.1 Maximally Spaced Projection Sequencing2.2 Principal Component Analysis Filtering3 Results3.1 Maximally Spaced Projection Sequencing3.2 Principal Component Analysis Filtering4 Discussion and ConclusionsChapter 18 Repetitive Measurements of Intrarenal Oxygenation In Vivo Using L Band Electron Paramagnetic Resonance1 Introduction2 Methods2.1 Animals2.2 LiPc Probe Preparations2.3 Insertion of Probes into Renal Tissue2.4 In Vivo Measurements with L Band EPR2.5 Statistical Analysis3 Results4 ConclusionsChapter 19 Quantitative Hypoxia Imaging for Treatment Planning of Radiotherapy1 Introduction2 Treatment Planning Based on Tumour Oxygenation3 Role of EPR Oximetry in PET Hypoxia Calibration for Treatment Planning Based on Tumour Oxygenation4 ConclusionsChapter 20 A New Flavonoid Regulates Angiogenesis and Reactive Oxygen Species Production1 Introduction2 Methods3 Results4 Discussion5 ConclusionChapter 21 Angiotensin II Reduces Transport-Dependent Oxygen Consumption but Increases Transport-Independent Oxygen Consumption in Immortalized Mouse Proximal Tubular Cells1 Introduction2 Material and Methods3 Results4 DiscussionChapter 22 Investigation of Cerebral Autoregulation in the Newborn Piglet During Anaesthesia and Surgery1 Introduction2 Methods3 Data Analysis4 Results5 DiscussionChapter 23 Influence of the Maternal Use of Labetalol on the Neurogenic Mechanism for Cerebral Autoregulation Assessed by Means of NIRS1 Introduction2 Methods3 Results4 Discussion and ConclusionChapter 24 Development of a Near Infrared MultiWavelength, Multi-Channel, Time-Resolved Spectrometer for Measuring Brain Tissue Haemodynamics and Metabolism1 Introduction2 Instrumentation and Methods3 Results4 ConclusionChapter 25 Simulating NIRS and MRS Measurements During Cerebral Hypoxia-Ischaemia in Piglets Using a Computational Model1 Introduction2 Experimental Methods and Protocol3 Group Analysis of Measurements4 Model5 Results6 DiscussionChapter 26 Analysis of Slow Wave Oscillations in Cerebral Haemodynamics and Metabolism Following Subarachnoid Haemorrhage1 Introduction2 Methods3 Results4 DiscussionChapter 27 Effects of Enriched Environment on Hippocampal Neuronal Cell Death and Neurogenesis in Rat Global Ischemia1 Introduction2 Methods3 Results4 DiscussionChapter 28 Automated Image Analysis for Diameters and Branching Points of Cerebral Penetrating Arteries and Veins Captured with Two-Photon Microscopy1 Introduction2 Methods2.1 Animal Experiments2.2 Image Analysis3 Results and Discussion3.1 Vessel Diameters of Penetrating Arteries and Emerging Veins3.2 Branching Points of Penetrating Arteries and Emerging Veins4 ConclusionsChapter 29 Cerebral Hemodynamic Change and Metabolic Alteration in Severe Hemorrhagic Shock1 Introduction2 Materials and Methods3 Results and Discussion4 ConclusionsChapter 30 Physiological Mechanism of Increase in Deoxyhemoglobin Concentration During Neuronal Activation in Patients with Cerebral Ischemia: A Simulation Study with the Balloon Model1 Introduction2 Methods2.1 The Balloon Model2.2 Simulation of Ischemia3 Results4 DiscussionChapter 31 Effect of Blood in the Cerebrospinal Fluid on the Accuracy of Cerebral Oxygenation Measured by Near Infrared Spectroscopy1 Introduction2 Material and Methods2.1 The Head Model2.2 Optical Properties of the Head and Cerebrospinal Fluid2.3 Forward Modeling and Measurement of Sensitivity3 Results4 Discussion and ConclusionChapter 32 Vessel Specific Imaging of Glucose Transfer with Fluorescent Glucose Analogue in Anesthetized Mouse Cortex1 Introduction2 Methods2.1 Experiments2.2 Image Analysis3 Results and Discussion3.1 Time–Intensity Curve of 2-NBDG3.2 Spatiotemporal Evolution of the 2-NBDG from Blood to Tissue Compartments4 ConclusionsChapter 33 Ischemic Pretreatment Delays Ischemic Brain Vasospasm Injury in Gerbils1 Introduction2 Methods2.1 Experiment 12.2 Experiment 22.3 Experiment 33 Results3.1 Effects of Ischemia on Vasoconstriction3.2 Effect of Ischemia Time on Postischemic Recovery of Physiologic Parameters3.3 Effect of Ischemic Pretreatment on Tissue Oxygenation and Tissue Damage4 DiscussionChapter 34 Changes in Cerebral Blood Oxygenation Induced by Active Standing Test in Children with POTS and NMS1 Introduction2 Methods2.1 Statistical Analysis3 Results3.1 Changes in Cerebral Blood Flow During Standing3.2 Changes in Cerebral Blood Oxygenation4 DiscussionChapter 35 Optical Imaging of Brain Activation in Gambian Infants1 Introduction2 Methods2.1 Data Acquisition Protocol2.2 Image Reconstruction3 Results4 ConclusionsChapter 36 Asymmetrical Changes in Cerebral Blood Oxygenation Induced by an Active Standing Test in Children with Postural Tachycardia Syndrome1 Introduction2 Methods3 Results4 Discussion4.1 Study LimitationsChapter 37 Changes of Cerebral Tissue Oxygen Saturation at Sleep Transitions in Adolescents1 Introduction2 Methods2.1 Subjects2.2 NIRS Measurement2.3 Post-processing2.4 Statistics3 Results4 Discussion and ConclusionsChapter 38 Influence of Subjective Happiness on the Prefrontal Brain Activity: An fNIRS Study1 Introduction2 Methods2.1 Subjects2.2 Evaluation Method2.2.1 Subjective Happiness2.2.2 Measurements of Brain Activity2.3 Experimental Procedures Stimuli3 Results3.1 Relationship Between NIRS Signals and SH3.2 Relationship Between SAM and SH4 Discussion4.1 Difference Between Left and Right PFC Functions4.2 Difference in Time5 ConclusionsChapter 39 Ginkobiloba Extract Improves Working Memory Performance in Middle-Aged Women: Role of Asymmetry of Prefrontal Cortex Activity During a Working Memory Task1 Introduction2 Methods2.1 Experimental Protocol2.2 Data Analysis3 Results4 DiscussionChapter 40 Bayesian Prediction of Anxiety Level in Aged People at Rest Using 2-Channel NIRS Data from Prefrontal Cortex1 Introduction2 Materials and Methods2.1 Experimental Settings2.2 NIRS Data2.3 Prediction2.3.1 Prediction Flow2.3.2 Prediction Algorithm3 Results4 DiscussionChapter 41 Short-Term Hypoxic Preconditioning Improved Survival Following Cardiac Arrest and Resuscitation in Rats1 Introduction2 Methods2.1 Animals and Hypoxic Preconditioning2.2 Induction of Transient Global Brain Ischemia2.3 Hippocampal Neuron Counts3 Results3.1 Physiological Variables3.2 Overall Survival Following Cardiac Arrest and Resuscitation3.3 Hippocampal Neuronal Death Following Cardiac Arrest and Resuscitation4 DiscussionChapter 42 Venular Valves and Retrograde Perfusion1 Introduction2 Formulation for a Cylindrical Model3 Confirmation of the Formulation Using Published Data4 Consideration of a Hemispherical Model for the Bicuspid Valves5 Discussion6 ConclusionChapter 43 Monitoring of Filter Patency During Carotid Artery Stenting Using Near-Infrared Spectroscopy with High Time-Resolution1 Introduction2 Methods3 Results4 Discussion5 ConclusionsChapter 44 Use of NIRS to Assess Effect of Training on Peripheral Muscle Oxygenation Changes in Elite Rugby Players Performing Repeated Supramaximal Cycling Tests1 Introduction2 Methods2.1 Experimental Overview2.1.1 Near-Infrared Spectroscopy Measurements3 Results4 ConclusionsChapter 45 Skeletal Muscle Deoxygenation Responses During Treadmill Exercise in Children1 Introduction2 Methods2.1 Subjects2.2 Experimental Design2.3 Statistics3 Results4 DiscussionChapter 46 Development of a Hybrid Microwave-Optical Thermoregulation Monitor for the Muscle1 Introduction2 Material and Methods2.1 Microwave Applicator Design2.2 The Biological Thermal Model2.3 The Optical Probe3 Results and Discussion4 ConclusionsChapter 47 Evaluation of a Textile-Based Near Infrared Spectroscopy System in Calf Muscle Oxygenation Measurements1 Introduction2 Materials and Methods2.1 Textile-Based NIRS Sensor (TexNIRS)2.2 Subjects2.3 Study Protocol3 Results4 Discussion and ConclusionChapter 48 Skin Temperature in Lower Hind Limb Subjected to Distal Vein Arterialization in Rats1 Introduction1.1 Methods2 Results2.1 Effects of DVA on Skin Temperature with Valve Destruction in the Femoral Vein only (DVAfem)2.2 Effects of DVA with Valve Disruption Throughout the Whole Length of the Femoral and Popliteal Veins (DVAfem/popl)3 Discussion3.1 General Aspects3.2 Skin Temperature on the Medial Thigh3.3 Skin Temperature Distal to the Knee in DVAfem3.4 Skin Temperature Distal to the Knee in DVAfem/popl4 Conclusion
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